Source:
E.coliContent:5µg
Overview
CNTFstandsforciliaryneurotrophicfactor,alsotermedmembrane-associatedneurotransmitterstimulatingfactor(MANS).HumanCNTFisarecombinantproteinoptimizedforuseincellculture,differentiationstudies,andfunctionalassays.
Applications
HumanCNTFmaybeusedforavarietyofapplications,including:
- Survivalfactorforneuronsandoligodendrocytes.
- Promotionofneurotransmittersynthesisandneuriteoutgrowthinneuronalpopulationsincludingastrocytes.
- Growthpromotionofparasympatheticneuronsandsympathetic,sensory,andspinalmotorneuronsinvitro.
- DifferentiationofProgenitorcellsinoligodendrocytesorastrocytes.
Details
Backgroundinformation
Ciliaryneurotrophicfactor(CNTF),alsoknownasmembrane-associatedneurotransmitterstimulatingfactor(MANS),isapotentneuralfactorthatwasinitiallypurifiedfromchickembryooculartissue.IntermsofneuronalspecificityCNTFoverlapswithneurotrophins,althoughitscellularlocalisation,receptorstructure,andsignalingpathwayaredistinctfromthoseoftheneurotrophinfamily.TheCNTFαreceptorhasbeenlocalizedtoskeletalmusclesandtothenervoussystem.Onereceptorsubunitisknownasgp130whichisalsoacomponentofreceptorsfortheleukaemiainhibitoryfactor(LIF),interleukin6(IL-6),interleukin11(IL-11),andoncostatinM(OSM).CNTFispresentinnormalperipheralnerves,localisedmainlyinthecytoplasmofmyelin-associatedSchwanncellsaswellasastrocytesinthecentralnervoussystem.Itpromotesthesurvivalofneuronsandoligodendrocytesaswellassensoryneurons,motorneurons,basalforebrainneurons,andtype2astrocytes.CNTFishighlyconservedacrossspeciesandexhibitscross-speciesactivity.
StimulationofTF-1cells
researchgrade:≥2×104U/mg
Qualitydescription
Research-gradecytokinesaresuitableforawidevarietyofcellcultureapplications.Theyaresterile-filteredpriortolyophilization.Generally,endotoxinlevelsare<0.1ng/μg(<1EU/μg),andpuritiesare>95%.Thebiologicalactivityistestedinappropriatebioassays.
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